RT Journal Article
SR Electronic
T1 Central Nervous System Metastases in Patients With Cervical Carcinoma
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1686
OP 1689
DO 10.1097/IGC.0000000000000827
VO 26
IS 9
A1 Bernardo Cacho-Díaz
A1 Nydia A. Lorenzana-Mendoza
A1 Rosa M. Michel-Ortega
A1 Gervith Reyes-Soto
A1 Alejandro Monroy-Sosa
A1 David Cantú de León
A1 Jorge L. Martínez-Tláhuel
A1 Angel Herrera-Gómez
A1 Martín Granados-García
YR 2016
UL http://ijgc.bmj.com/content/26/9/1686.abstract
AB Introduction Cervical cancer (CC) is the most common malignancy throughout developing countries, although considered rare, central nervous system metastasis (CNSm) does occur.Objective This study aimed to describe our experiences and compare them to other published cases.Materials and Methods From May 2009 to August 2015, the files of all patients with CC treated at our referral center were reviewed.Results We found 27 patients with CC and CNSm. Mean age at the time of CNS diagnosis was 50 ± 11 years, mean interval between initial CC and CNSm was 46 months; the most frequent initial International Federation of Gynecology and Obstetrics stage was IIB with 17 patients followed by IB in 4. Fifty-nine percent of patients had lung metastases at the time CNSm were diagnosed. Headache was the most common symptom, followed by weakness, altered mental status, and ataxia/cerebellar. Mean survival was 8.2 months after CNSm was discovered; 3 patients are still alive.Conclusions The present study describes the largest series of patients with CNSm from CC; this rare complication should be suspected in patients with CC who present with headache, ataxia, cranial nerve palsy, visual disturbance, altered mental status, focal weakness, or other neurological symptom, without other plausible explanation.