TY - JOUR T1 - Central Nervous System Metastases in Patients With Cervical Carcinoma JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1686 LP - 1689 DO - 10.1097/IGC.0000000000000827 VL - 26 IS - 9 AU - Bernardo Cacho-Díaz AU - Nydia A. Lorenzana-Mendoza AU - Rosa M. Michel-Ortega AU - Gervith Reyes-Soto AU - Alejandro Monroy-Sosa AU - David Cantú de León AU - Jorge L. Martínez-Tláhuel AU - Angel Herrera-Gómez AU - Martín Granados-García Y1 - 2016/11/01 UR - http://ijgc.bmj.com/content/26/9/1686.abstract N2 - Introduction Cervical cancer (CC) is the most common malignancy throughout developing countries, although considered rare, central nervous system metastasis (CNSm) does occur.Objective This study aimed to describe our experiences and compare them to other published cases.Materials and Methods From May 2009 to August 2015, the files of all patients with CC treated at our referral center were reviewed.Results We found 27 patients with CC and CNSm. Mean age at the time of CNS diagnosis was 50 ± 11 years, mean interval between initial CC and CNSm was 46 months; the most frequent initial International Federation of Gynecology and Obstetrics stage was IIB with 17 patients followed by IB in 4. Fifty-nine percent of patients had lung metastases at the time CNSm were diagnosed. Headache was the most common symptom, followed by weakness, altered mental status, and ataxia/cerebellar. Mean survival was 8.2 months after CNSm was discovered; 3 patients are still alive.Conclusions The present study describes the largest series of patients with CNSm from CC; this rare complication should be suspected in patients with CC who present with headache, ataxia, cranial nerve palsy, visual disturbance, altered mental status, focal weakness, or other neurological symptom, without other plausible explanation. ER -