PT - JOURNAL ARTICLE AU - Josefa Marcos-Sanmartín AU - José Antonio López Fernández AU - José Sánchez-Payá AU - Óscar Cruz Piñero-Sánchez AU - María José Román-Sánchez AU - María Asunción Quijada-Cazorla AU - María Amparo Candela-Hidalgo AU - Juan Carlos Martínez-Escoriza TI - Does the Type of Surgical Approach and the Use of Uterine Manipulators Influence the Disease-Free Survival and Recurrence Rates in Early-Stage Endometrial Cancer? AID - 10.1097/IGC.0000000000000808 DP - 2016 Nov 01 TA - International Journal of Gynecologic Cancer PG - 1722--1726 VI - 26 IP - 9 4099 - http://ijgc.bmj.com/content/26/9/1722.short 4100 - http://ijgc.bmj.com/content/26/9/1722.full SO - Int J Gynecol Cancer2016 Nov 01; 26 AB - Objective The purpose of this study was to compare the long-term safety, disease-free survival, and recurrence rate of total laparoscopic hysterectomy using uterine manipulator and abdominal hysterectomy in the surgical treatment in early-stage endometrial cancer.Study Design This was a cohort study of 147 patients with clinical endometrial cancer (laparoscopic surgery group, 77 women; laparotomy group, 70 women). Data were evaluated and analyzed by intention-to-treat principle, and survival data of stage I endometrial cancer (129 patients; 66 from laparoscopic surgery group and 60 from laparotomy group) were estimated by using the Kaplan-Meier curves.Results After a follow-up period of 60 months for both laparoscopic surgery and laparotomy groups, no significant difference in the cumulative recurrence rates (7.4% and 13.1%, P = 0.091) and overall survival (97.1% and 95.1%, P = 0.592) was detected between both groups of stage I endometrial cancer. Conversion to laparotomy occurred in 10.4% (8/77) of the laparoscopic procedures. Laparoscopic hysterectomy was associated with less use of pain medication (P = 0.001) and a shorter hospital stay (P < 0.001), but the procedure took longer than laparotomic hysterectomy (P < 0.001). The proportion of patients with intraoperative and long-term complications was not significantly different between both groups. The use of uterine manipulators did not have increased recurrence rate in patients treated with laparoscopic approach.Conclusions The laparoscopic surgery approach to early-stage endometrial cancer using uterine manipulators is as safe and effective as the laparotomic approach.