PT  - JOURNAL ARTICLE
AU  - Mikel Gorostidi Pulgar
AU  - Begoña Diaz de la Noval
AU  - Blanca Gil-Ibañez
AU  - Victor Lago Leal
AU  - Ibon Jaunarena Marin
AU  - Pablo Padilla Iserte
TI  - Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks
AID  - 10.1097/IGC.0000000000001022
DP  - 2017 Jul 01
TA  - International Journal of Gynecologic Cancer
PG  - 1191--1199
VI  - 27
IP  - 6
4099  - http://ijgc.bmj.com/content/27/6/1191.short
4100  - http://ijgc.bmj.com/content/27/6/1191.full
SO  - Int J Gynecol Cancer2017 Jul 01; 27
AB  - Objective The purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist.Methods/Materials Between October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.Results Most respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.Conclusions Results suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined.