PT  - JOURNAL ARTICLE
AU  - Ghanim Khatib
AU  - Ümran Küçükgöz Güleç
AU  - Ahmet Bariş Güzel
AU  - Berk Uygur
AU  - Gülşah Seydaoğlu
AU  - Derya Gümürdülü
AU  - Mehmet Ali Vardar
TI  - A Single-Institution Radical Surgery Results in Stage IB2/IIA2 (Bulky) Cervical Cancer
AID  - 10.1097/IGC.0000000000000786
DP  - 2016 Oct 01
TA  - International Journal of Gynecologic Cancer
PG  - 1480--1484
VI  - 26
IP  - 8
4099  - http://ijgc.bmj.com/content/26/8/1480.short
4100  - http://ijgc.bmj.com/content/26/8/1480.full
SO  - Int J Gynecol Cancer2016 Oct 01; 26
AB  - Objective The aim of this study is to evaluate the results of radical surgery in patients with stage IB2 to IIA2 cervical cancer who were operated on at our center between 2002 and 2015.Materials and Methods Forty-seven cases of patients with stage IB2/IIA2 cervical cancer who underwent primary radical surgery between 2002 and 2015 were enrolled in this study. Patients’ files and pathological reports were retrospectively reviewed. Surgical, pathological, and clinical variables were analyzed and their impact on survival period was researched. Disease-free survival and overall survival periods were determined using the Kaplan-Meier test. The P value was considered significant if less than 0.05.Results Type C2 radical hysterectomy with lymphadenectomy (5 pelvic, 42 pelvic and para-aortic) was performed for all of the 47 patients in accordance with the Querleu-Morrow classification. Thirty-three of the cases were stage Ib2 and 14 cases were IIa2. Five years of overall survival was 80%. Recurrence was noted in 10 (7 pelvic, 3 extrapelvic) patients. Adjuvant therapies were needed for 83% of the patients. A univariate analysis was made for all included variables in this research and, other than recurrence, none of them was found to be statistically significant on OS and DFS.Conclusions Although adjuvant therapies are often resorted to, primary radical surgery is also a reasonable treatment option for stage IB2/IIA2 cervical cancer, especially in young premenopausal patients when preserving ovarian functions is desired.