PT  - JOURNAL ARTICLE
AU  - Mona Hosh
AU  - Sarah Antar
AU  - Ahmed Nazzal
AU  - Mahmoud Warda
AU  - Ahmed Gibreel
AU  - Basel Refky
TI  - Uterine Sarcoma: Analysis of 13,089 Cases Based on Surveillance, Epidemiology, and End Results Database
AID  - 10.1097/IGC.0000000000000720
DP  - 2016 Jul 01
TA  - International Journal of Gynecologic Cancer
PG  - 1098--1104
VI  - 26
IP  - 6
4099  - http://ijgc.bmj.com/content/26/6/1098.short
4100  - http://ijgc.bmj.com/content/26/6/1098.full
SO  - Int J Gynecol Cancer2016 Jul 01; 26
AB  - Objective The aim was to study the incidence and survival of patients with uterine sarcoma diagnosed in the period from 2000 to 2012 based on Surveillance, Epidemiology, and End Results (SEER) database.Methods All 18 registries of the SEER database were used to select cases. We included women aged 30 years or older diagnosed with uterine sarcoma. Histological subtypes were defined as leiomyosarcoma, carcinosarcoma, stromal sarcoma, adenosarcoma, and sarcoma not otherwise specified according to the 2003 World Health Organization classification. Using SEER*Stat software version 8.1.2. We calculated the age-adjusted incidence rates, extent of disease at time of diagnosis, and survival rates with different treatment modalities for white, black, and other races. Univariate and multivariate Cox proportional hazards analysis were done to examine factors affecting survival.Results We identified 13,089 patients diagnosed with uterine sarcoma in the period from 2000 to 2012. The age-adjusted incidence rate for patients aged 50 years or older was more than that of younger patients (6.4/105 vs 1.5/105, P < 0.0001). Also, the age-adjusted incidence rate for black women was twice that of white women (7.3/105 vs 3.5/105, P < 0.0001). Carcinosarcoma was the most commonly diagnosed subtype followed by leiomyosarcoma. Women aged 50 years or older had worse survival than those younger than 50 years (hazard ratio, 1.78; 95% confidence interval, 1.64–1.92; P < 0.001). The overall survival of patients who had surgery with radiation was better than those who had surgery alone (hazard ratio, 0.89; 95% confidence interval, 0.83–0.95; P < 0.001). In women with localized disease, surgery was associated with better survival than surgery with radiation (66.4% vs 74.4%, P < 0.00001).Conclusions Uterine sarcoma is an aggressive tumor that occurs more in old age and among women of black race. Poor survival was associated with old age, black race, and advanced disease stage. Radiotherapy in patients with localized stage does not improve the survival.