RT Journal Article
SR Electronic
T1 Surgical Treatment of Metastatic Ovarian Tumors From Extragenital Primary Sites
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 688
OP 696
DO 10.1097/IGC.0000000000000673
VO 26
IS 4
A1 Veysel Sal
A1 Fuat Demirkiran
A1 Samet Topuz
A1 Ilker Kahramanoglu
A1 Ibrahim Yalcin
A1 Tugan Bese
A1 Hamdullah Sozen
A1 Nedim Tokgozoglu
A1 Yavuz Salihoglu
A1 Hasan Turan
A1 Cem Iyibozkurt
A1 Tugba Kolomuc
A1 Nigar Sofiyeva
A1 Sinan Berkman
A1 Macit Arvas
YR 2016
UL http://ijgc.bmj.com/content/26/4/688.abstract
AB Objective The purpose of this study was to investigate the outcomes and prognostic factors of metastasectomy in patients with metastatic ovarian tumors from extragenital primary sites.Materials and Methods All patients with pathologically confirmed metastatic ovarian tumors between January 1997 and June 2015 were included in this study. A total of 131 patients were identified. The data were obtained from the patients’ medical records. Clinicopathological features were evaluated by both univariate and multivariate analyses.Results The primary sites were colorectal region (53.4%), stomach (26%), and breast (13%). Preoperative serum CA 125 and CA 19-9 levels were elevated in 29.4% and 39.8% of the patients, respectively. Cytoreductive surgery was performed in 41.2% of the patients. Seventy-three (55.7%) patients had no residual disease after surgery. Sixty-six (49.6%) patients had combined metastases at the time of the surgery to sites including the liver, pancreas, lung, bone, lymph nodes, bladder, or the intestine. With a median follow-up of 33 months, the median survival time was 22 months. The estimated 5-year survival probability is 0.26. On univariate analysis, primary cancer site, combined metastasis outside the ovaries, residual disease, preoperative serum CA 125 and CA 19-9 levels, and histologic type were significant parameters for overall survival. Furthermore, residual disease, preoperative serum CA 19-9 level, and primary cancer site were found to be independent prognostic factors on multivariate analysis.Conclusions The most common primary sites for ovarian metastasis are gastrointestinal tract. Metastasectomy may have beneficial effects on survival, especially if the residual disease is less than 5 mm. Prospective studies warranted to evaluate the value of metastasectomy in patients with ovarian metastasis.