TY - JOUR T1 - Prognostic Factors in Adult Granulosa Cell Tumor: A Long Follow-Up at a Single Center JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 619 LP - 625 DO - 10.1097/IGC.0000000000000659 VL - 26 IS - 4 AU - Alper Karalok AU - Taner Turan AU - Isin Ureyen AU - Tolga Tasci AU - Derman Basaran AU - Sevgi Koc AU - Nurettin Boran AU - M. Faruk Kose AU - Gokhan Tulunay Y1 - 2016/05/01 UR - http://ijgc.bmj.com/content/26/4/619.abstract N2 - Objective In this study, we aimed to demonstrate characteristics, recurrence rates, survival numbers, and factors associated with survival of patients with adult granulosa cell tumor (AGCT) from a single institution. Our secondary goal was to evaluate the necessity of staging surgery and the importance of a comprehensive lymphadenectomy in these patients.Methods The data of 158 patients in our institution who were diagnosed with AGCT between 1988 and 2013 were evaluated. The data were obtained from the files of the patients, electronic database of the gynecologic oncology clinic, operation notes, and pathology records.Results The median (range) age of the patients was 50.3 (22–82) years. The main symptom was postmenopausal bleeding (25.9%). Seventy-six percent of the patients underwent staging surgery including lymphadenectomy. Among these patients, 3 (2.5%) had lymph node metastasis. The median (range) follow-up time was 97 (1–296) months. In the follow-up period, 18 patients (12.5%) had recurrence. Menopausal status (P = 0.016), advanced age (P = 0.024), cyst rupture (P = 0.001), poorly differentiated tumor (P = 0.002), and advanced stage (P < 0.001) were associated with recurrence. Stage was the only independent prognostic factor for the development of recurrence. None of the patients had lymph node failure.Conclusions In the present study with a long follow-up period and in which most of the patients had staging surgery including lymphadenectomy (76.6%), lymph node recurrence was not observed and the total recurrence rate (12.5%) was lower than that reported in the literature. The study showed the importance of surgical staging in patients with AGCT. ER -