PT  - JOURNAL ARTICLE
AU  - Gregory M. Gressel
AU  - Lisbet S. Lundsberg
AU  - Gary Altwerger
AU  - Tasleem Katchi
AU  - Masoud Azodi
AU  - Peter E. Schwartz
AU  - Elena S. Ratner
TI  - Factors Predictive of Improved Survival in Patients With Brain Metastases From Gynecologic Cancer: A Single Institution Retrospective Study of 47 Cases and Review of the Literature
AID  - 10.1097/IGC.0000000000000554
DP  - 2015 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1711--1716
VI  - 25
IP  - 9
4099  - http://ijgc.bmj.com/content/25/9/1711.short
4100  - http://ijgc.bmj.com/content/25/9/1711.full
SO  - Int J Gynecol Cancer2015 Nov 01; 25
AB  - Objective The reported incidence of brain metastasis from epithelial ovarian cancer (EOC), endometrial cancer (EC), and cervical cancer (CC) is exceedingly rare. As the long-term survival for patients with gynecologic cancer increases, there has been a corresponding increase in the number of diagnosed intracranial metastases. We seek to report our experience with managing brain metastatic disease (BMD) in patients with gynecologic cancer.Methods A retrospective review of all patients with EOC, EC, and CC at our institution revealed 47 patients with concurrent BMD between 2000 and 2013. Demographic data, risk factors, treatment modalities, progression-free data, and overall survival data were collected.Results Median survival time in patients with brain metastasis from EOC, EC, and CC was 9.0, 4.5, and 3.0 months, respectively. Two-year overall survival rates were 31.6%, 13.6%, and 0%, respectively. Patients received surgery, radiation therapy alone, palliative care, or radiation plus surgery. Radiation combined with surgical resection resulted in a significant hazards ratio of 0.36 (95% confidence interval, 0.15–0.86), compared with radiation alone.Conclusions Our report provides a large single-institution experience of brain metastases from gynecologic cancer. Patients with BMD have poor prognoses; however, treatment with multimodal therapy including surgical resection and radiation may prolong overall survival.