TY - JOUR T1 - Long Follow-up of Patients With Locally Advanced Cervical Cancer Treated With Concomitant Chemobrachyradiotherapy With Cisplatin and Ifosfamide Followed by Consolidation Chemotherapy JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 315 LP - 319 DO - 10.1097/IGC.0000000000000336 VL - 25 IS - 2 AU - Branka Petric Miše AU - Tihana Boraska Jelavic AU - Ante Strikic AU - Darijo Hrepic AU - Krešimir Tomic AU - Wolfgang Hamm AU - Snježana Tomic AU - Tomislav Prskalo AU - Eduard Vrdoljak Y1 - 2015/02/01 UR - http://ijgc.bmj.com/content/25/2/315.abstract N2 - Objectives Locally advanced cervical cancer (LACC) is one of the leading health problems of the developing countries. We present long-term outcomes of treatment with a concomitant chemobrachyradiotherapy followed by consolidation chemotherapy regimen.Materials and Methods We treated 118 patients with LACC (International Federation of Gynecology and Obstetrics stages IB2-IVA) with external radiotherapy (50 Gy in 25 fractions) and concomitant chemobrachyradiotherapy (low-dose rate). Chemotherapy was applied during brachyradiotherapy (cisplatin on day 1 in combination with 24-hour infusion of ifosfamide and mesna uroprotection). Four cycles of consolidation chemotherapy were given starting 4 weeks after the second concomitant chemobrachyradiotherapy cycle.Results After median follow-up period of 99.3 months, we observed acceptable acute and late toxicity, local control rate of 97.5%, and an overall survival of 74.6% at 96 months.Conclusions Chemobrachyradiotherapy regimen followed by consolidation chemotherapy described in this article is a valuable treatment option for LACC. ER -