TY - JOUR T1 - Lymph Node Status Did Not Significantly Improve the Predictability of Survival in Patients With Clinically Early-Stage Endometrial Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1449 LP - 1454 DO - 10.1097/IGC.0000000000000237 VL - 24 IS - 8 AU - Hyo Sook Bae AU - Jong-Min Lee AU - Jae-Kwan Lee AU - Jae-Weon Kim AU - Chi-Heum Cho AU - Seok-Mo Kim AU - Sang-Yoon Park AU - Chan-Yong Park AU - Ki-Tae Kim AU - Sokbom Kang Y1 - 2014/10/01 UR - http://ijgc.bmj.com/content/24/8/1449.abstract N2 - Objective The aim of this study was to determine whether knowledge of lymph node status improves survival prediction in clinically early-stage endometrial cancer.Methods The records of 661 patients with apparently uterine-confined disease were reviewed. The performance in predicting overall survival and cause-specific survival was compared between a multivariate prognostic model with nodal status and a model without nodal status by calculating Harrell concordance index.Results Among 661 patients with clinically early-stage endometrial cancer, the lymph node metastasis rate was 8.3% (55/661). Lymph node metastasis independently associated with cause-specific survival only when no stratification according to adjuvant treatment was applied (P = 0.035). After stratification according to adjuvant radiotherapy, lymph node status marginally associated with cause-specific survival (P = 0.073), whereas myometrial invasion retained its strong association with cause-specific survival (P < 0.001). However, there was no significant difference in the performance of the survival model using only uterine factors and the model using lymph node status and uterine factors (concordance index, 0.77 vs 0.77, respectively; P = 0.798).Conclusions Knowledge of lymph node status did not significantly improve the performance of survival prediction in apparently uterine-confined endometrial cancer, although it was independently associated with survival. In the patients with clinically early-stage endometrial cancer, the accuracy of the prediction of survival was comparable between risk grouping without lymph node status and that including lymph node status. ER -