RT Journal Article SR Electronic T1 Maximum Standardized Uptake Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Ovarian Clear Cell Adenocarcinoma JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 1190 OP 1194 DO 10.1097/IGC.0000000000000180 VO 24 IS 7 A1 Haruhisa Konishi A1 Kazuhiro Takehara A1 Atsumi Kojima A1 Shinichi Okame A1 Yasuko Yamamoto A1 Yuko Shiroyama A1 Takashi Yokoyama A1 Takayoshi Nogawa A1 Yoshifumi Sugawara YR 2014 UL http://ijgc.bmj.com/content/24/7/1190.abstract AB Background Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for diagnosing malignant tumors. Intracellular FDG uptake is measured as the standardized uptake value (SUV), which differs depending on tumor characteristics. This study investigated differences in maximum SUV (SUVmax) according to histologic type in ovarian epithelial cancer and the relationship of SUVmax with prognosis.Methods This study included 80 patients with ovarian epithelial cancer based on histopathologic findings at surgery and who had undergone PET/CT before treatment. Maximum SUV on PET/CT of primary lesions and histopathology were compared based on histologic type, and the prognosis associated with different SUVmax was evaluated.Results Clinical tumor stage was I in 35 patients, II in 8, III in 25, and IV in 12. Histologic type was serous adenocarcinoma (AC) in 33 patients, clear cell AC in 27, endometrioid AC in 15, and mucinous AC in 5. Median SUVmax was lower in mucinous AC (2.76) and clear cell AC (4.9) than in serous AC (11.4) or endometrioid AC (11.4). Overall, median SUVmax was lower in clinical stage I (5.37) than in clinical stage ≥II (10.3). However, in both clear cell AC and endometrioid AC, when histologic evaluation was possible, no difference was seen between stage I and stage ≥II. Moreover, in clear cell AC, the 5-year survival rate was significantly higher in the low-SUVmax group (100%) than in the high-SUVmax group (43.0%, P = 0.009).Conclusions Maximum SUV on preoperative FDG-PET/CT in ovarian epithelial cancer differs according to histologic type. In clear cell AC, SUVmax may represent a prognostic factor.