TY - JOUR T1 - Study of Biomolecular and Clinical Prognostic Factors in Patients With Cancer of the Vulva Undergoing Surgical Treatment JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 766 LP - 772 DO - 10.1097/IGC.0000000000000103 VL - 24 IS - 4 AU - Paulo Henrique Zanvettor AU - Deraldo Fernando Falcão Filho AU - Fernando Augusto Soares AU - Adson Roberto Santos Neves AU - Leonardo Oliveira Palmeira Y1 - 2014/05/01 UR - http://ijgc.bmj.com/content/24/4/766.abstract N2 - Introduction Cancers of the vulva account for 3% to 5% of all cancers of the female genital. This study was conducted to evaluate clinical, pathological, and molecular prognostic factors in patients with cancer of the vulva.Methods Patients with squamous cell carcinoma of the vulva who had undergone surgical treatment at the Department of Pelvic Surgery and Gynecology Service, Aristides Maltez Hospital, between June 1993 and June 2011 were selected. Clinical, epidemiological, pathological, and molecular characteristics related to the prognosis of these patients were evaluated in relation to the prognosis. In the molecular evaluation, we studied the expression of p53 and matrix metalloproteinase 2 by immunohistochemistry.Results Seventy-five patients were eligible for the study. In multivariable analysis, factors related to survival were as follows: tumor size larger than 4 cm (P = 0.014), an invasion depth greater than 2 mm (P = 0.023) and matrix metalloproteinase 2 expression in more than 50% of the tumor cells (P = 0.046). With the use of the relative risks of the factors identified in the multivariable analysis, a point count was developed for a prognostic classification (the score classifies patients into 3 categories).Conclusions A tumor size larger than 4 cm, an invasion depth greater than 2 mm, and metalloproteinase 2 expression in more than 50% of the tumor cells seem to be related to lower overall survival rate in patients with cancer of the vulva undergoing surgical treatment. A classification of the patient’s prognosis can be performed using a point count based on these relative risks. ER -