PT - JOURNAL ARTICLE AU - Ioannis C. Kotsopoulos AU - Alexios Papanikolaou AU - Alexandros F. Lambropoulos AU - Konstantinos T. Papazisis AU - Dimitrios Tsolakidis AU - Panagiota Touplikioti AU - Basil C. Tarlatzis TI - Serous Ovarian Cancer Signaling Pathways AID - 10.1097/IGC.0000000000000079 DP - 2014 Mar 01 TA - International Journal of Gynecologic Cancer PG - 410--417 VI - 24 IP - 3 4099 - http://ijgc.bmj.com/content/24/3/410.short 4100 - http://ijgc.bmj.com/content/24/3/410.full SO - Int J Gynecol Cancer2014 Mar 01; 24 AB - Abstract Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.