RT Journal Article
SR Electronic
T1 Clinical Outcome of Isolated Serous Tubal Intraepithelial Carcinomas (STIC)
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1603
OP 1611
DO 10.1097/IGC.0b013e3182a80ac8
VO 23
IS 9
A1 Stephanie L. Wethington
A1 Kay J. Park
A1 Robert A. Soslow
A1 Noah D. Kauff
A1 Carol L. Brown
A1 Fanny Dao
A1 Ebunoluwa Otegbeye
A1 Yukio Sonoda
A1 Nadeem R. Abu-Rustum
A1 Richard R. Barakat
A1 Douglas A. Levine
A1 Ginger J. Gardner
YR 2013
UL http://ijgc.bmj.com/content/23/9/1603.abstract
AB Objective Risk-reducing salpingo-oophorectomy (RRSO) is recommended for women with BRCA mutation due to increased risk of pelvic serous carcinoma. Serous tubal intraepithelial carcinoma (STIC) is a pathologic finding of unknown clinical significance. This study evaluates the clinical outcome of patients with isolated STIC.Materials/Methods We retrospectively reviewed the medical records of consecutive patients with a germline BRCA1/2 mutation or a high-risk personal or family history of ovarian cancer who underwent RRSO between January 2006 and June 2011. All patients had peritoneal washings collected. All surgical specimens were assessed using the sectioning and extensively examining the fimbria protocol, with immunohistochemistry when indicated. p53 signature lesions and secretory cell outgrowths were excluded.Results Of 593 patients who underwent RRSO, isolated STIC was diagnosed in 12 patients (2%). Five patients (42%) were BRCA1 positive, 5 patients (42%) were BRCA2 positive, and 2 patients (17%) had high-risk family history. Preoperatively, all patients with STIC had normal CA-125 levels and/or pelvic imaging results. Seven patients underwent hysterectomy and omentectomy, 6 patients (46%) had pelvic node dissections, and 5 patients (39%) had para-aortic node dissections. With the exception of positive peritoneal washings in 1 patient, no invasive or metastatic disease was identified. No patient received adjuvant chemotherapy. At median follow-up of 28 months (range, 16–44 months), no recurrences have been identified.Conclusions Among the cases of isolated STIC after RRSO reported in the literature, the yield of surgical staging is low, and short-term clinical outcomes are favorable. Peritoneal washings are the most common site of disease spread. Individualized management is warranted until additional data become available.