RT Journal Article
SR Electronic
T1 Vitamin D Receptor BsmІ Polymorphism and Ovarian Cancer Risk: A Meta-Analysis
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1178
OP 1183
DO 10.1097/IGC.0b013e31829db839
VO 23
IS 7
A1 Xue Qin
A1 Yu Lu
A1 Aiping Qin
A1 Zhiping Chen
A1 Qiliu Peng
A1 Yan Deng
A1 Li Xie
A1 Jian Wang
A1 Ruolin Li
A1 Jie Zeng
A1 Shan Li
A1 Jinmin Zhao
YR 2013
UL http://ijgc.bmj.com/content/23/7/1178.abstract
AB Objective Vitamin D receptor (VDR) FokI polymorphism has been reported to influence ovarian cancer (OC) susceptibility, but the association between VDR BsmI polymorphism and OC risk remains controversial. To clarify the relationship between them, we performed a meta-analysis.Methods A comprehensive literature search was conducted to examine all the eligible studies of VDR BsmI polymorphism and OC risk. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to assess the strength of this association.Results Seven separate comparisons consisting of 1977 OC cases and 2832 healthy controls were included in our meta-analysis. The pooled analyses showed no significant association between VDR BsmI G/A polymorphism and OC in all of the comparisons (AA vs GG: OR, 1.01; P = 0.919; AG vs GG: OR, 1.12; P = 0.087; AG + AA vs GG: OR, 1.10; P = 0.146; AA vs AG + GG: OR, 0.96; P = 0.629). However, subgroup analysis showed a significant contribution of the dominant inheritance model to OC development in the European group: AG + AA vs GG (OR, 1.43; P = 0.029); AG vs GG (OR, 1.46; P = 0.031).Conclusions Vitamin D receptor BsmI G/A gene variant might be a moderate risk factor of OC development in the European population instead of North America or Asian population.