PT - JOURNAL ARTICLE AU - Xue Qin AU - Yu Lu AU - Aiping Qin AU - Zhiping Chen AU - Qiliu Peng AU - Yan Deng AU - Li Xie AU - Jian Wang AU - Ruolin Li AU - Jie Zeng AU - Shan Li AU - Jinmin Zhao TI - Vitamin D Receptor BsmІ Polymorphism and Ovarian Cancer Risk: A Meta-Analysis AID - 10.1097/IGC.0b013e31829db839 DP - 2013 Sep 01 TA - International Journal of Gynecologic Cancer PG - 1178--1183 VI - 23 IP - 7 4099 - http://ijgc.bmj.com/content/23/7/1178.short 4100 - http://ijgc.bmj.com/content/23/7/1178.full SO - Int J Gynecol Cancer2013 Sep 01; 23 AB - Objective Vitamin D receptor (VDR) FokI polymorphism has been reported to influence ovarian cancer (OC) susceptibility, but the association between VDR BsmI polymorphism and OC risk remains controversial. To clarify the relationship between them, we performed a meta-analysis.Methods A comprehensive literature search was conducted to examine all the eligible studies of VDR BsmI polymorphism and OC risk. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to assess the strength of this association.Results Seven separate comparisons consisting of 1977 OC cases and 2832 healthy controls were included in our meta-analysis. The pooled analyses showed no significant association between VDR BsmI G/A polymorphism and OC in all of the comparisons (AA vs GG: OR, 1.01; P = 0.919; AG vs GG: OR, 1.12; P = 0.087; AG + AA vs GG: OR, 1.10; P = 0.146; AA vs AG + GG: OR, 0.96; P = 0.629). However, subgroup analysis showed a significant contribution of the dominant inheritance model to OC development in the European group: AG + AA vs GG (OR, 1.43; P = 0.029); AG vs GG (OR, 1.46; P = 0.031).Conclusions Vitamin D receptor BsmI G/A gene variant might be a moderate risk factor of OC development in the European population instead of North America or Asian population.