PT - JOURNAL ARTICLE AU - Maria Inês Rosa AU - Geraldo Doneda Silva AU - Priscyla Waleska Targino de Azedo Simões AU - Meriene Viquetti Souza AU - Ana Paula Ronzani Panatto AU - Carla Sasso Simon AU - Kristian Madeira AU - Lidia Rossi Medeiros TI - The Prevalence of Human Papillomavirus in Ovarian Cancer: A Systematic Review AID - 10.1097/IGC.0b013e318280f3e0 DP - 2013 Mar 01 TA - International Journal of Gynecologic Cancer PG - 437--441 VI - 23 IP - 3 4099 - http://ijgc.bmj.com/content/23/3/437.short 4100 - http://ijgc.bmj.com/content/23/3/437.full SO - Int J Gynecol Cancer2013 Mar 01; 23 AB - Objective We performed a systematic review and a meta-analysis to estimate the prevalence of human papillomavirus (HPV) in ovarian cancer.Methods A comprehensive search of the Cochrane Library, MEDLINE, CANCERLIT, LILACS, Grey literature and EMBASE was performed for articles published from January 1990 to March 2012. The following MeSH (Medical Subject Headings) terms were searched: “ovarian tumor” or “ovarian cancers” and “HPV” or “human papillomavirus.” Included were case-control and cross-sectional studies, prospective or retrospective, that evaluated clinical ovarian cancer and provided a clear description of the use of in situ hybridization, Southern blot hybridization, and polymerase chain reaction. The statistical analysis was performed using REVMAN 5.0.Results In total, 24 primary studies were included in this meta-analysis. Studies from 11 countries on 3 continents contained data on HPV and ovarian cancer, including 889 subjects. Overall, the HPV prevalence in patients with ovarian cancer was 17.5 (95% confidence interval [CI], 15.0%–20.0%). Human papillomavirus prevalence ranged from 4.0% (95% CI, 1.7%–6.3%) in Europe to 31.4% (95% CI, 26.9%–35.9%) in Asia. An aggregate of 4 case-control studies from Asia showed an odds ratio of 2.48 (95% CI, 0.64–9.57).Conclusions We found a high prevalence of HPV-positive DNA in ovarian cancer cases, but the role of HPV in ovarian cancer remains inconclusive. Further studies are needed to control case to answer this question.