TY - JOUR T1 - G801A Polymorphism of Human Stromal Cell–Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1297 LP - 1302 DO - 10.1097/IGC.0b013e318265d334 VL - 22 IS - 8 AU - Yi-Torng Tee AU - Shun-Fa Yang AU - Po-Hui Wang AU - Hsiu-Ting Tsai AU - Long-Yau Lin AU - Shu-Kuei Lee AU - Chiung-Ling Liao AU - Jinghau Tsai Chang AU - Yang-Tse Shih Y1 - 2012/10/01 UR - http://ijgc.bmj.com/content/22/8/1297.abstract N2 - Objective This study aimed to investigate the association of stromal cell–derived factor 1 (SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in Mid-Taiwan women.Materials and Methods Four hundred ninety-eight blood samples were collected from 161 patients with neoplasia of uterine cervix, including 76 cancer patients, 61 patients with high-grade dysplasia, and 24 with low-grade dysplasia, and 337 healthy controls who lived in Mid-Taiwan. Polymorphism of the SDF-1 gene was examined using polymerase chain reaction–restriction fragment length polymorphism.Results For SDF-1 gene polymorphisms, the wild-type homozygous alleles (G/G) yielded 100- and 193-bp products, the heterozygous alleles (G/A) yielded 100-, 193- and 293-bp products, whereas the mutated-type homozygous alleles (A/A) yielded a 293-bp product. We found no significant difference in genotypes or alleles distribution of SDF-1 polymorphisms between patients with cervical neoplasia and healthy women (P = 0.530). Compared with the homozygous GG subgroup, GA and AA subgroups do not increase the risk of cervical neoplasia.Conclusions Although the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia. ER -