PT - JOURNAL ARTICLE AU - Seiji Mabuchi AU - Mika Okazawa AU - Yasuto Kinose AU - Koji Matsuo AU - Masateru Fujiwara AU - Osamu Suzuki AU - Eiichi Morii AU - Shoji Kamiura AU - Kazuhiko Ogawa AU - Tadashi Kimura TI - Comparison of the Prognoses of FIGO Stage I to Stage II Adenosquamous Carcinoma and Adenocarcinoma of the Uterine Cervix Treated With Radical Hysterectomy AID - 10.1097/IGC.0b013e31826b5d9b DP - 2012 Oct 01 TA - International Journal of Gynecologic Cancer PG - 1389--1397 VI - 22 IP - 8 4099 - http://ijgc.bmj.com/content/22/8/1389.short 4100 - http://ijgc.bmj.com/content/22/8/1389.full SO - Int J Gynecol Cancer2012 Oct 01; 22 AB - Objectives To evaluate the significance of adenosquamous carcinoma (ASC) compared with adenocarcinoma (AC) in the survival of surgically treated early-stage cervical cancer.Methods We retrospectively reviewed the medical records of 163 patients with International Federation of Gynecology and Obstetrics stage IA2 to stage IIB cervical cancer who had been treated with radical hysterectomy with or without adjuvant radiotherapy between January 1998 and December 2008. The patients were classified according to the following: (1) histological subtype (ASC group or AC group) and (2) pathological risk factors (low-risk or intermediate/high-risk group). Survival was evaluated using the Kaplan-Meier method and compared using the log-rank test. Multivariate analysis of progression-free survival (PFS) was performed using the Cox proportional hazards regression model to investigate the prognostic significance of histological subtype.Results Clinicopathological characteristics were similar between the ASC and AC histology groups. Patients with the ASC histology displayed a PFS rate similar to that of the patients with the AC histology in both the low-risk and intermediate/high-risk groups. Neither the recurrence rate nor the pattern of recurrence differed between the ASC group and the AC group. Univariate analysis revealed that patients with pelvic lymph node metastasis and parametrial invasion achieved significantly shorter PFS than those without these risk factors.Conclusions Characteristics of the patients and the tumors as well as survival outcomes of ASC were comparable to adenocarcinoma of early-stage uterine cervix treated with radical hysterectomy. Our results in part support that the management of ASC could be the same as the one of AC of the uterine cervix.