PT - JOURNAL ARTICLE AU - Saara Bryk AU - Eero Pukkala AU - Anniina Färkkilä AU - Markku Heikinheimo AU - Leila Unkila-Kallio AU - Annika Riska TI - Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors AID - 10.1097/IGC.0000000000001333 DP - 2018 Oct 01 TA - International Journal of Gynecologic Cancer PG - 1529--1534 VI - 28 IP - 8 4099 - http://ijgc.bmj.com/content/28/8/1529.short 4100 - http://ijgc.bmj.com/content/28/8/1529.full SO - Int J Gynecol Cancer2018 Oct 01; 28 AB - Objective The aim of this study was to determine the incidence of new primary malignancies after adult-type granulosa cell tumor (AGCT) and the incidence of AGCT after breast and uterine cancer using nationwide population-based registry data.Methods We used the Finnish Cancer Registry to identify all patients diagnosed with AGCT in 1968 to 2013 (n = 986). The number of subsequent primary malignancies among women with AGCT and the number of AGCTs in women with previous breast or uterine cancer were compared with the expected number of cases and expressed as standardized incidence ratios (SIRs).Results There were 122 cases of subsequent cancers diagnosed at least 6 months after the primary diagnosis of AGCT (SIR, 1.09; 95% confidence interval [CI], 0.91–1.3). In particular, the observed number of cancers of the soft tissue (SIR, 4.13; 95% CI, 1.33–12.8), thyroid (SIR, 3.42; 95% CI, 1.54–7.62), and leukemia (SIR, 2.67; 95% CI, 0.98–5.82) exceeded the number of expected cases. The SIR for breast cancers after AGCT was 1.26 (95% CI, 0.92–1.73), and the SIR for AGCT after breast cancer was 1.59 (95% CI, 1.04–2.29). The risk for subsequent AGCT was more than 2-fold in breast cancer patients younger than 50 years, and over 15 years after primary diagnosis.Conclusions There is an increased risk for thyroid and soft tissue cancer as well as leukemia after AGCT, which may be associated with late effects of carcinogenic treatments and possibly shared risk factors. After breast cancer, the risk for AGCT was higher, which may indicate a shared hormonal etiology.