TY - JOUR T1 - Number of Nodes Removed With Inguinofemoral Lymphadenectomy and Risk of Isolated Groin Recurrence in Women With FIGO Stage IB–II Squamous Cell Vulvar Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1600 LP - 1605 DO - 10.1097/IGC.0000000000001326 VL - 28 IS - 8 AU - Francesco Sopracordevole AU - Nicolò Clemente AU - Giorgio Giorda AU - Vincenzo Canzonieri AU - Lara Alessandrini AU - Anna del Fabro AU - Matteo Serri AU - Andrea Ciavattini Y1 - 2018/10/01 UR - http://ijgc.bmj.com/content/28/8/1600.abstract N2 - Aim The aim of this study was to evaluate if the lymph node count from inguinofemoral lymphadenectomy impacted the risk of isolated groin recurrence in patients with node-negative squamous cell vulvar cancer.Materials and Methods This is a retrospective cohort study of women with squamous cell vulvar cancer (stage IB–II according to the 2009 Revised International Federation of Gynecology and Obstetrics staging system) who underwent primary radical vulvar surgery and groin lymphadenectomy between January 2005 and December 2014. Patients' sociodemographic characteristics, the disease characteristics, the number of nodes removed from each groin, and the oncologic outcome were evaluated. A cutoff value of at least 6 nodes removed from each groin was used to define the adequacy of inguinofemoral dissection.Results Seventy-six patients, fulfilling the study inclusion criteria, were considered. The mean number of nodes removed (bilaterally) was 14.5 (±5.3, SD), with a range of 2 to 29 nodes. Thirty-three women (43.4%) had less than 6 nodes removed from each groin. In the whole study cohort, 4 cases of isolated groin recurrence (5.3%) were detected, and all these recurrences developed in patients with less than 6 nodes removed. Considering the demographic, clinical, and histopathological characteristics potentially related to the risk of groin recurrence, only the number of nodes removed showed a significant correlation.Conclusions Women treated for vulvar cancer in which less than 6 nodes are removed from each groin are at higher risk of groin recurrence. ER -