TY - JOUR T1 - Ovarian preservation for low-grade endometrial stromal sarcoma: a systematic review of the literature and meta-analysis JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 126 LP - 132 DO - 10.1136/ijgc-2018-000063 VL - 29 IS - 1 AU - Dimitrios Nasioudis AU - Emily M Ko AU - Georgios Kolovos AU - Stylianos Vagios AU - Dimitrios Kalliouris AU - Robert L Giuntoli Y1 - 2019/01/01 UR - http://ijgc.bmj.com/content/29/1/126.abstract N2 - Objective To evaluate the effect of ovarian preservation on oncologic outcomes for women with low-grade endometrial stromal sarcoma of the uterus.Methods A systematic search of the Medline, Embase, Cohrane, and Web of Science databases was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies including patients with low-grade endometrial stromal sarcoma who had hysterectomy were identified. Data on tumor recurrence and death rate were pooled using a random effects model.Results A total of 17 studies met the inclusion criteria and reported on 786 patients. Based on available information, ovarian preservation was noted in 190 patients while 501 had bilateral salpingo-oophorectomy. A significantly increased tumor recurrence rate was observed in the ovarian preservation group (89/190, 46.8%) compared with the bilateral salpingo-oophorectomy group (121/501, 24.2%) (OR 2.70, 95% CI 1.39 to 5.28). Based on data from 162 patients, no difference in death rate was noted between the ovarian preservation (2/34, 5.9%) and bilateral salpingo-oophorectomy (9/128, 7%) groups (OR 0.80, 95% CI 0.18 to 3.47).Conclusions Approximately one-quarter of patients with low-grade endometrial stromal sarcoma were managed with ovarian preservation. These women experienced a higher recurrence rate. Hormone exposure may be responsible for this elevated risk. Given the apparent high salvage rate, however, ovarian preservation may be an option only in a well-informed patient population. ER -