@article {Lopes188, author = {Andre Lopes and Ronaldo Lucio Rangel Costa and Raphael di Paula and Cristina Anton and Ytauan Calheiros and Vivian Sartorelli and Yara Mitie Kanashiro and Jo{\~a}o Alves de Lima and Alayne Yamada and Gabriel Lowndes de S Pinto and Maria Regina Vianna and Maria Luiza Nogueira Dias Genta and Ulysses Ribeiro, Jr and Marcelo Oliveira dos Santos}, title = {Cardiophrenic lymph node resection in cytoreduction for primary advanced or recurrent epithelial ovarian carcinoma: a cohort study}, volume = {29}, number = {1}, pages = {188--194}, year = {2019}, doi = {10.1136/ijgc-2018-000073}, publisher = {BMJ Specialist Journals}, abstract = {Objectives To evaluate the clinical outcomes of epithelial ovarian carcinoma patients who underwent cardiophrenic lymph node resection.Methods We retrospectively reviewed the records of all surgically treated patients with advanced epithelial ovarian carcinoma (stages IIIC{\textendash}IV) who underwent cardiophrenic lymph node resection between 2002 and 2018. Only those in whom cardiophrenic lymph node involvement was the only detectable extra-abdominal disease were included. Patients with suspected cardiophrenic lymph node metastasis on staging images underwent a transdiaphragmatic incision to access the para-cardiac space after complete abdominal cytoreduction achievement. Data on disease-free survival, overall survival, and surgical procedures performed concurrently with cardiophrenic lymph node resection were collected.Results Of the total 456 patients, 29 underwent cardiophrenic lymph node resection; of these, 24 patients met the inclusion criteria. Twenty-two, one, and one patients had high grade serous epithelial ovarian carcinoma, low grade epithelial ovarian carcinoma, and ovarian carcinosarcoma, respectively. Ten patients had recurrent disease (recurrence group). Fourteen patients underwent cytoreduction during primary treatment (primary debulking group); four underwent cytoreduction after neoadjuvant chemotherapy. Cardiophrenic lymph node resection was performed on the right side in 19 patients, left side in three, and bilaterally in two. The average procedural duration was 28 minutes, with minimal blood loss and no severe complications. Twenty-one patients had cardiophrenic lymph node positivity. The median disease-free intervals were 17 and 12 months in the recurrent and primary debulking surgery groups, respectively. The mediastinum was the first recurrence site in 10 patients. Five patients developed brain metastases. Five patients had an overall survival beyond 50 months.Conclusions Although rare, the cardiophrenic lymph nodes may be a site of metastasis of ovarian cancer. Although their presence might indicate future recurrence, some patients may achieve long-term survival. Resection should be considered in cases of suspicious involvement to confirm extra-abdominal disease and achieve complete cytoreduction.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/29/1/188}, eprint = {https://ijgc.bmj.com/content/29/1/188.full.pdf}, journal = {International Journal of Gynecologic Cancer} }