PT  - JOURNAL ARTICLE
AU  - Mary Cairns
AU  - Kate S. Cuschieri
AU  - Heather A. Cubie
AU  - Margaret E. Cruickshank
TI  - High-Risk HPV Genotyping in the Follow-Up of Women Treated Conservatively for Microinvasive Cervical Cancer
AID  - 10.1111/IGC.0b013e3181c3a6b6
DP  - 2010 Jan 01
TA  - International Journal of Gynecologic Cancer
PG  - 154-157--154-157
VI  - 20
IP  - 1
4099  - http://ijgc.bmj.com/content/20/1/154-157.short
4100  - http://ijgc.bmj.com/content/20/1/154-157.full
SO  - Int J Gynecol Cancer2010 Jan 01; 20
AB  - Objectives: Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease.Study Design: Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991.Results: We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%.Conclusion: Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.