PT - JOURNAL ARTICLE AU - Keiichiro Nakamura AU - Junichi Kodama AU - Yoshihiro Okumura AU - Atsushi Hongo AU - Susumu Kanazawa AU - Yuji Hiramatsu TI - The SUVmax of <sup>18</sup>F-FDG PET Correlates With Histological Grade in Endometrial Cancer AID - 10.1111/IGC.0b013e3181c3a288 DP - 2010 Jan 01 TA - International Journal of Gynecologic Cancer PG - 110-115--110-115 VI - 20 IP - 1 4099 - http://ijgc.bmj.com/content/20/1/110-115.short 4100 - http://ijgc.bmj.com/content/20/1/110-115.full SO - Int J Gynecol Cancer2010 Jan 01; 20 AB - Objectives: The objectives of this study were to assess the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose (18F-FDG) by a primary tumor of endometrial cancer with the use of positron emission tomography/computed tomography (PET/CT) and to assess its association with the clinical importance of the disease.Methods: 18F-fluorodeoxyglucose PET/CT scan was performed on 44 participants within 2 weeks before surgery. 18F-fluorodeoxyglucose uptake was quantified by calculating the SUVmax. The distribution of cases that scored positive for each of the biological parameters examined was correlated with the SUVmax of the 18F-FDG PET/CT and the glucose transporter-1 expression status obtained by immunohistochemistry.Results: The mean SUVmax of the primary endometrial cancer tumors was 17.6 (range, 3.04-34.74). There were significant correlations between the SUVmax of the primary tumor and the International Federation of Gynecology and Obstetrics (FIGO) grade (P &lt; 0.001), maximum tumor size (P &lt; 0.001), and glucose transporter-1 expression (P &lt; 0.001). Furthermore, multivariate analysis showed that the FIGO grade was most significantly identified as a relation factor of SUVmax (≥17.6) for endometrial cancer (P = 0.017). The present findings indicate that a significant relationship was seen between the SUVmax and the FIGO grade in endometrial cancer.Conclusion: We propose that the primary tumor's SUVmax obtained from 18F-FDG PET/CT may be associated with aggressive biological characteristics in endometrial cancer.