RT Journal Article
SR Electronic
T1 Frequent Loss of Tumor Suppressor ARID1A Protein Expression in Adenocarcinomas/Adenosquamous Carcinomas of the Uterine Cervix
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 208
OP 212
DO 10.1097/IGC.0b013e3182313d78
VO 22
IS 2
A1 Atsuko Katagiri
A1 Kentaro Nakayama
A1 Mohammed Tanjimur Rahman
A1 Munmun Rahman
A1 Hiroshi Katagiri
A1 Masako Ishikawa
A1 Tomoka Ishibashi
A1 Kouji Iida
A1 Yoshiro Otsuki
A1 Satoru Nakayama
A1 Kohji Miyazaki
YR 2012
UL http://ijgc.bmj.com/content/22/2/208.abstract
AB Objectives Expression of ARID1A (the adenine, thymine-rich interactive domain 1A), a putative tumor suppressor, has recently been shown to be lost in several tumor types. This study investigated whether ARID1A expression was also lost in cervical squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas.Methods A total of 91 patients with cervical carcinoma were enrolled. Cervical carcinoma specimens were examined for ARID1A protein expression by immunohistochemistry. The correlations between the loss of ARID1A expression and clinicopathological characteristics, and prognosis were investigated.Results Using immunohistochemistry, the frequency of loss of ARID1A expression in adenocarcinomas/adenosquamous carcinomas (31.1% [14/45]) was significantly higher than that in squamous cell carcinomas (6.5% [3/46]; P = 0.0017). There was no significant association between the loss of ARID1A expression and International Federation of Gynecology and Obstetrics staging, lymphovascular space invasion, lymph node metastasis, age, and Ki-67 LI in cervical adenocarcinomas/adenosquamous carcinomas. Loss of ARID1A expression was not correlated with shorter overall/disease-free survival in cervical adenocarcinomas/adenosquamous carcinomas.Conclusions In conclusion, this study provides the first evidence of the frequent loss of ARID1A protein expression in cervical adenocarcinomas/adenosquamous carcinomas. No significant differences between ARID1A positive and negative cases were observed with respect to any clinicopathological features examined.