PT - JOURNAL ARTICLE AU - Robert L. Giuntoli AU - Melissa A. Gerardi AU - Anna V. Yemelyanova AU - Stefanie M. Ueda AU - Aimee C. Fleury AU - Teresa P. Diaz-Montes AU - Robert E. Bristow TI - Stage I Noninvasive and Minimally Invasive Uterine Serous Carcinoma: Comprehensive Staging Associated With Improved Survival AID - 10.1097/IGC.0b013e318238df4d DP - 2012 Feb 01 TA - International Journal of Gynecologic Cancer PG - 273--279 VI - 22 IP - 2 4099 - http://ijgc.bmj.com/content/22/2/273.short 4100 - http://ijgc.bmj.com/content/22/2/273.full SO - Int J Gynecol Cancer2012 Feb 01; 22 AB - Objective The aim of this study was to determine if comprehensive surgical staging is a better predictor of outcome than incomplete staging for women with stage I noninvasive or minimally invasive (⩽3 mm) uterine serous carcinoma (USC).Methods Retrospective chart review was used to identify patients undergoing hysterectomy at the Johns Hopkins Hospital from 1989 to 2010. Relevant clinical and pathologic data were extracted. Patients with noninvasive and minimally invasive (⩽3-mm myometrial invasion) USC were identified. Stage was assigned based on the 2009 International Federation of Gynecology and Obstetrics endometrial cancer criteria. Survival curves were generated using the Kaplan-Meier method.Results We identified 63 patients with noninvasive or minimally invasive (⩽3 mm) USC. Stages I, II, III, and IV disease were noted in 65% (41/63), 6% (4/63), 14% (9/63), and 14% (9/63) of the patients, respectively. Lower stage was associated with a significantly improved disease-specific survival (P = 0.001). Comprehensive staging, including total hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, omentectomy, and peritoneal biopsies, was completed in 29% (12/41) of the patients with stage I disease. There were no disease-specific deaths in the comprehensive staging group. Compared with incomplete staging, comprehensive staging was associated with a significantly improved disease-specific survival (P = 0.039).Conclusions Patients with stage I noninvasive and minimally invasive USC on comprehensive staging have an excellent prognosis. Adjuvant therapy may not benefit this patient population.