PT  - JOURNAL ARTICLE
AU  - Belén De La Torriente Benito, Carmen
AU  - García, Antonio Carballo
AU  - Cristina Fernández Rísquez, Ana
AU  - Joaquín Hijona Elósegui, Jesús
AU  - Andrés, Margarita Gil
TI  - 955 Effect of a coriolus versicolor-based vaginal gel as a conservative treatment for HR-HPV-dependent HSIL in pregnant women
AID  - 10.1136/ijgc-2024-ESGO.475
DP  - 2024 Mar 01
TA  - International Journal of Gynecologic Cancer
PG  - A244--A244
VI  - 34
IP  - Suppl 1
4099  - http://ijgc.bmj.com/content/34/Suppl_1/A244.2.short
4100  - http://ijgc.bmj.com/content/34/Suppl_1/A244.2.full
SO  - Int J Gynecol Cancer2024 Mar 01; 34
AB  - Introduction/Background Human papilloma virus (HPV) infection is the most common venereal infection and the main causative agent of the 99% of cervical cancer cases. HPV persistence, particularly with genotype 16, may lead to different grade squamous intraepithelial lesions that can result in high-grade lesions (HSIL) and cervical cancer. Surgical excisional treatment of HSIL/CIN2 and 3 during pregnancy is contraindicated due to the high rate of complications, including probability of abortion and preterm birth. Thus, the management of an HSIL diagnose during pregnancy remains to be a challenge to both, the patient and the clinician. With these three clinical case reports, we aimed to evaluate the effect of a Coriolus versicolor-based vaginal gel in the conservative management of CIN2 lesions during pregnancy.Methodology Here we present three clinical case reports involving pregnant women between 26 and 34 years old with high-risk HPV (HR-HPV) genotypes including 16, 18, 31, 39, and 45, and who were diagnosed with HSIL/CIN2–3 through colposcopy and biopsies. Patients were prescribed with Coriolus versicolor-based vaginal gel (1 cannula/day for 1 month + 1 cannula/alternate days for 2 months) gel as a conservative treatment. Follow-up colposcopy, cytology and HPV tests were performed over time for monitoring patients.Results All patients showed a regression of CIN2/3 to CIN1 lesions. Two of them, achieved the regression after 3 months of conservative treatment with Coriolus versicolor-based vaginal gel and one the other patient after 6 months of conservative treatment with Coriolus versicolor-based vaginal gel. None of the patients reported any negative effect associated with the use of Coriolus versicolor-based vaginal gel.Conclusion The Coriolus versicolor-based vaginal gel treatment leads to regression of HSIL/CIN2 in pregnant women with HR-HPV. This conservative treatment approach represents a clinical advantage in patients during their ’wait and see’ period who are not candidates for an excisional surgery.Disclosures .