RT Journal Article
SR Electronic
T1 The Quest for Ovarian Cancer Screening Biomarkers: Are We on the Right Road?
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP S35
OP S40
DO 10.1097/IGC.0b013e318251ccaa
VO 22
IS S1
A1 Lokshin, Anna E.
YR 2012
UL http://ijgc.bmj.com/content/22/S1/S35.abstract
AB Abstract Recent discoveries in the field of biomarkers for screening and early detection of ovarian cancer (OC) identified current needs for biomarkers capable of recognizing preclinical disease. The suggested approaches are (1) development of highly analytically sensitive CA 125 assays capable of detecting CA 125 released from small cancerous and preneoplastic lesions; (2) identification of biomarkers effective in CA 125–negative cases; and (3) performing biomarker discovery in samples obtained from patients with prophylactic bilateral salpingo-oophorectomy with pathologically confirmed preneoplastic lesions, or in appropriate animal models of ovarian cancer.