PT  - JOURNAL ARTICLE
AU  - Lokshin, Anna E.
TI  - The Quest for Ovarian Cancer Screening Biomarkers: Are We on the Right Road?
AID  - 10.1097/IGC.0b013e318251ccaa
DP  - 2012 May 01
TA  - International Journal of Gynecologic Cancer
PG  - S35--S40
VI  - 22
IP  - S1
4099  - http://ijgc.bmj.com/content/22/S1/S35.short
4100  - http://ijgc.bmj.com/content/22/S1/S35.full
SO  - Int J Gynecol Cancer2012 May 01; 22
AB  - Abstract Recent discoveries in the field of biomarkers for screening and early detection of ovarian cancer (OC) identified current needs for biomarkers capable of recognizing preclinical disease. The suggested approaches are (1) development of highly analytically sensitive CA 125 assays capable of detecting CA 125 released from small cancerous and preneoplastic lesions; (2) identification of biomarkers effective in CA 125–negative cases; and (3) performing biomarker discovery in samples obtained from patients with prophylactic bilateral salpingo-oophorectomy with pathologically confirmed preneoplastic lesions, or in appropriate animal models of ovarian cancer.