TY - JOUR T1 - Perirenal Adiposity is Associated With Lower Progression-Free Survival From Ovarian Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 285 LP - 292 DO - 10.1097/IGC.0000000000001165 VL - 28 IS - 2 AU - Yan Zhang AU - Adriana M. Coletta AU - Pamela K. Allen AU - Aaroh M. Parikh AU - Matthes Cox-Mattin AU - Larissa A. Meyer AU - Charlotte C. Sun AU - Karen M. Basen-Engquist AU - Karen H. Lu AU - Ann H. Klopp Y1 - 2018/02/01 UR - http://ijgc.bmj.com/content/28/2/285.abstract N2 - Objectives Abdominal obesity is linked with a higher risk of developing ovarian cancer. However, the link between abdominal obesity and survival after diagnosis of ovarian cancer is unknown. The purpose of this study was to determine the impact of abdominal obesity on progression-free survival in patients with ovarian cancer.Methods Among 258 patients, visceral and subcutaneous adipose tissue volume, along with perirenal adipose tissue thickness (a visceral adiposity proxy measure) was retrospectively measured from abdominal computed tomography (CT) scans obtained within 6 months of ovarian cancer diagnosis. Progression-free survival was computed using the Kaplan-Meier method and log-rank tests. Univariate and multivariate Cox proportional hazards analysis was used to determine relationships between measures of abdominal obesity and clinical variables in relation to progression-free survival.Results Patients with perirenal adipose tissue thickness greater than 5 mm(median) had lower rates of progression-free survival at 5 years compared with patients with perirenal adipose tissue thickness less than 5 mm (45.6% vs 53.8%, respectively). Perirenal adipose tissue thickness less than 5 mm was associated with lower rates of progression-free survival on multivariate analysis (hazard ratio = 1.37; 95% confidence interval, 1.03–1.82). There was no correlation with other metrics of abdominal adiposity on progression-free survival in univariate or multivariate analysis.Conclusions Our data suggest that perirenal adipose, but not body mass index, visceral, or subcutaneous fat volume that were measured within 6 months from diagnosis, is associated with lower rates of progression-free survival in ovarian cancer. ER -