PT  - JOURNAL ARTICLE
AU  - Lago, Victor
AU  - Cruz, Marta Arnáez De La
AU  - Padilla-Iserte, Pablo
AU  - Gurrea, Marta
AU  - Matute, Luis
AU  - Lopez, Susana
AU  - Montero, Beatriz
AU  - Domingo, Santiago
TI  - #617 Accuracy of sentinel lymph node detection with indocyanine green fluorescence (ICG) and ultrastaging in early ovarian cancer
AID  - 10.1136/ijgc-2023-ESGO.615
DP  - 2023 Sep 01
TA  - International Journal of Gynecologic Cancer
PG  - A295--A295
VI  - 33
IP  - Suppl 3
4099  - http://ijgc.bmj.com/content/33/Suppl_3/A295.2.short
4100  - http://ijgc.bmj.com/content/33/Suppl_3/A295.2.full
SO  - Int J Gynecol Cancer2023 Sep 01; 33
AB  - Introduction/Background Nowadays, Sentinel Lymph node-SLN biopsy is the gold standard lymph node status assessment in many gynecological tumors. To known the node status is especially important for prognosis in apparent early-stage ovarian cancer. It could be a perfect setting for the use of this technique as we previously demonstrated its feasibility in a pilot study and in a clinical trial. SLN detection allows to know more information with less morbidity.Methodology Between December 2021–2022 patients with apparent early-stage ovarian cancer prospectively underwent intraoperative-ICG for SLN biopsy and subsequent ultrastaging followed by full staging surgery. The primary objective was to stablish the accuracy of ICG tracer to detection of SLN and validate ultrastaging analysis for metastasis detection.Results In total, 15 patients were included. The surgery indication was in 33.3% cases due to an adnexal masse and 66.7% for re-staging propose. Surgery was performed by laparoscopy in 93.3% of cases.The mean age was 53 years. Regarding the histologic features, 33.3% were low grade and 66.7% high grade, The most frequent histotype was serous (53.3%), followed by endometrioid (26.7%) and clear-cell (20%). The mean tumor size was 99mm.The site of injection were the utero-ovarian and infundibulo-pelvic stumps. We used ICG tracer (0.2 ml; 1,25 mg/ml) and the technique described in SENTOV Trial. The detection rate were 83%(10/12) and 100%(15/15) for pelvic and para-aortic nodes respectively. The mean lymph nodes harvested in the subsequent lymphadenectomy were 14±6 and 15±8 pelvic and para-aortic lymph nodes respectively.The final FIGO stage was IA in 40%, IC in 53.3% 40% and IIB in 6.7%. No lymph node metastasis were found not in SLN after ultrastaging . 2 cases (13%) were up-staged due to positivity of peritoneal washing and other due to pelvic peritoneum involvementConclusion Use of ICG tracer shows promising results for SLN biopsy in early-stage ovarian cancer.Disclosures No disclosure