PT  - JOURNAL ARTICLE
AU  - Huang, S. E.
AU  - Huang, S. C.
AU  - Lee, W. Y.
AU  - Hsu, K.-F.
TI  - Pseudo- Meigs' syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth factor expression
AID  - 10.1136/ijgc-00009577-200807000-00039
DP  - 2008 Jul 01
TA  - International Journal of Gynecologic Cancer
PG  - 851--853
VI  - 18
IP  - 4
4099  - http://ijgc.bmj.com/content/18/4/851.short
4100  - http://ijgc.bmj.com/content/18/4/851.full
SO  - Int J Gynecol Cancer2008 Jul 01; 18
AB  - Smooth muscle tumor of uncertain malignant potential (STUMP) presenting as pseudo-Meigs' syndrome with low vascular endothelial growth factor (VEGF) expression has not been reported in previous literature. Here, we report a case of uterine STUMP associated with ascites and pleural effusion, which was resolved completely after hysterectomy. A 47-year-old woman presented to the clinic with a complaint of progressive abdominal distension for several months. A large movable, painless pelvic mass located upward above the umbilical level was palpated. Sonography and computed tomography showed a hypervascular solid pelvic mass measuring 20 × 17 × 15 cm in size associated with ascites and right pleural effusion. Laparotomy revealed a large uterine mass with ascites in the abdomen. Total hysterectomy and left-side salpingo-oophorectomy were performed. The final pathologic report revealed a STUMP tumor with low expression of VEGF by immunohistochemistry. A follow-up chest X-ray revealed that the pleural effusion was resolved completely 1 week postoperatively. The patient is doing well without recurrence in the following 2 years. Uterine STUMP tumor may cause pseudo-Meigs' syndrome. However, the ascites or the pleural effusion may not be induced by VEGF, known as vascular permeability factor, in our case.