RT Journal Article
SR Electronic
T1 Does sentinel node mapping impact morbidity and quality of life in endometrial cancer?
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP ijgc-2023-004555
DO 10.1136/ijgc-2023-004555
A1 Goncalves, Bruna Tirapelli
A1 Dos Reis, Ricardo
A1 Ribeiro, Reitan
A1 Moretti-Marques, Renato
A1 Schamme, Fernanda Karoline
A1 Oliveira, Gabriela Silva
A1 Tsunoda, Audrey Tieko
A1 Alvarenga-Bezerra, Vanessa
A1 Lopes, Andre
A1 Pastore, Caroline Batista Pinheiro
A1 Kumagai, Lillian Yuri
A1 Faloppa, Carlos Chaves
A1 Mantoan, Henrique
A1 Badiglian-Filho, Levon
A1 De Brot, Louise
A1 Andrade, Carlos Eduardo Mattos Cunha
A1 Baiocchi, Glauco
YR 2023
UL http://ijgc.bmj.com/content/early/2023/09/12/ijgc-2023-004555.abstract
AB Objectives To evaluate the prevalence of post-operative complications and quality of life (QoL) related to sentinel lymph node (SLN) biopsy vs systematic lymphadenectomy in endometrial cancer.Methods A prospective cohort included women with early-stage endometrial carcinoma who underwent lymph node staging, grouped as follows: SLN group (sentinel lymph node only) and SLN+LND group (sentinel lymph node biopsy with addition of systematic lymphadenectomy). The patients had at least 12 months of follow-up, and QoL was assessed by European Organization for Research and Treatment of Cervical Cancer Quality of Life Questionnaire 30 (EORTC-QLQ-C30) and EORTC-QLQ-Cx24. Lymphedema was also assessed by clinical evaluation and perimetry.Results 152 patients were included: 113 (74.3%) in the SLN group and 39 (25.7%) in the SLN+LND group. Intra-operative surgical complications occurred in 2 (1.3%) cases, and all belonged to SLN+LND group. Patients undergoing SLN+LND had higher overall complication rates than those undergoing SLN alone (33.3% vs 14.2%; p=0.011), even after adjusting for confound factors (OR=3.45, 95% CI 1.40 to 8.47; p=0.007). The SLN+LND group had longer surgical time (p=0.001) and need for admission to the intensive care unit (p=0.001). Moreover, the incidence of lymphocele was found in eight cases in the SLN+LND group (0 vs 20.5%; p<0.001). There were no differences in lymphedema rate after clinical evaluation and perimetry. However, the lymphedema score was highest when lymphedema was reported by clinical examination at 6 months (30.1 vs 7.8; p<0.001) and at 12 months (36.3 vs 6.0; p<0.001). Regarding the overall assessment of QoL, there was no difference between groups at 12 months of follow-up.Conclusions There was a higher overall rate of complications for the group undergoing systematic lymphadenectomy, as well as higher rates of lymphocele and lymphedema according to the symptom score. No difference was found in overall QoL between SLN and SLN+LND groups.Data are available upon reasonable request. The data and material will be available by the authors upon reasonable request.