PT - JOURNAL ARTICLE AU - N. Bozkurt AU - K. Yuce AU - M. Basaran AU - S. Gariboglu AU - F. Kose AU - A. Ayhan TI - Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients AID - 10.1136/ijgc-00009577-200601000-00014 DP - 2006 Jan 01 TA - International Journal of Gynecologic Cancer PG - 83--86 VI - 16 IP - 1 4099 - http://ijgc.bmj.com/content/16/1/83.short 4100 - http://ijgc.bmj.com/content/16/1/83.full SO - Int J Gynecol Cancer2006 Jan 01; 16 AB - Forty-two consecutive patients with advanced epithelial ovarian cancer who underwent primary surgical treatment were evaluated. The control group comprised 21 patients who had undergone surgery associated with benign pathologies. Forty-one patients had stage III disease except one who had stage IV. Optimal debulking (<1 cm) was performed in all the patients who subsequently received chemotherapy. Based on the results of the second-look laparotomy and follow-up, the patients were divided into three groups: the first group had negative second-look laparotomy or no evidence of disease during follow-up (n = 21), the second group had positive second-look laparotomy or progressive disease (n = 21), and the third was the control group (n = 21). Interleukin-12 (IL-12) levels were measured in preoperative serum and intraoperative ascites samples for all the patients. The mean serum IL-12 levels (±SD) in serum (S) and ascites (A) were as follows: in the first group, S: 108.44 ± 76.40 pg/mL and A: 330.93 ± 125.25 pg/mL; in the second group, S: 51.80 ± 40.95 pg/mL and A: 206.89 ± 113.47 pg/mL; and in the control group, S: 36.55 ± 33.16 pg/mL and A: 93.62 ± 73.07 pg/mL (P = 0.01). In the patients with advanced ovarian cancer, IL-12 levels in serum and ascites were higher compared to the levels of the controls. Also, there was an inverse relationship between initial serum and ascitic IL-12 levels and disease progression.