@article {Bozkurt83, author = {N. Bozkurt and K. Yuce and M. Basaran and S. Gariboglu and F. Kose and A. Ayhan}, title = {Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients}, volume = {16}, number = {1}, pages = {83--86}, year = {2006}, doi = {10.1136/ijgc-00009577-200601000-00014}, publisher = {BMJ Specialist Journals}, abstract = {Forty-two consecutive patients with advanced epithelial ovarian cancer who underwent primary surgical treatment were evaluated. The control group comprised 21 patients who had undergone surgery associated with benign pathologies. Forty-one patients had stage III disease except one who had stage IV. Optimal debulking (\<1 cm) was performed in all the patients who subsequently received chemotherapy. Based on the results of the second-look laparotomy and follow-up, the patients were divided into three groups: the first group had negative second-look laparotomy or no evidence of disease during follow-up (n = 21), the second group had positive second-look laparotomy or progressive disease (n = 21), and the third was the control group (n = 21). Interleukin-12 (IL-12) levels were measured in preoperative serum and intraoperative ascites samples for all the patients. The mean serum IL-12 levels ({\textpm}SD) in serum (S) and ascites (A) were as follows: in the first group, S: 108.44 {\textpm} 76.40 pg/mL and A: 330.93 {\textpm} 125.25 pg/mL; in the second group, S: 51.80 {\textpm} 40.95 pg/mL and A: 206.89 {\textpm} 113.47 pg/mL; and in the control group, S: 36.55 {\textpm} 33.16 pg/mL and A: 93.62 {\textpm} 73.07 pg/mL (P = 0.01). In the patients with advanced ovarian cancer, IL-12 levels in serum and ascites were higher compared to the levels of the controls. Also, there was an inverse relationship between initial serum and ascitic IL-12 levels and disease progression.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/16/1/83}, eprint = {https://ijgc.bmj.com/content/16/1/83.full.pdf}, journal = {International Journal of Gynecologic Cancer} }