TY - JOUR T1 - Survival and Disease Relapse in Surgical Stage I Endometrioid Adenocarcinoma of the Uterus After Adjuvant Vaginal Vault Brachytherapy JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 564-569 LP - 564-569 DO - 10.1111/IGC.0b013e3181d7ce94 VL - 20 IS - 4 AU - Vinita Jaggi Kumar AU - Chia Yin Nin AU - Lim Yong Kuei AU - Khoo Tan Hs AU - Richard Yeo AU - Philip Yam Kwai Lam Y1 - 2010/05/01 UR - http://ijgc.bmj.com/content/20/4/564-569.abstract N2 - Introduction: Advanced age, deep myoinvasion, whole cavity or lower uterine segment tumors, poor differentiation, and lymphvascular space invasion are known to increase recurrence risk and adversely affect survival in stage I endometrioid adenocarcinoma of the uterus.Objectives: To ascertain survival rates, failure patterns, and salvageability and to correlate adverse histopathologic effects to recurrences in these patients.Methods: Data of 162 patients with surgical stage I endometrioid adenocarcinoma of the uterus with an increased risk of recurrence were reviewed from the year 1997 to 2008 at KK Gynaecological Cancer Centre, Singapore. Each patient underwent surgical staging and histopathologic evaluation and received high-dose rate vaginal vault brachytherapy. The data of all patients were discussed in a multidisciplinary meeting.Results: The mean patient age was 58.9 years. Most patients (54.3%) had surgical stage IC endometrioid adenocarcinoma, whereas the rest had stage IB. Grade 2 tumors were seen in 53.7% of the patients and grade 3 in 21.61%. The mean follow-up duration was 52.9 months, with a maximum of 11.5 years. Five- and 10-year survival rates were 94% and 89%, respectively. There were 9 recurrences (5.56%). Stage IC had 77.78% recurrences, whereas stage IB had 22.22%, the median time being 19 months. The initial 3 years had 77.78% relapses. There was no recurrence in grade 3 tumors, with a 100% 5-year survival rate for stage IC grade 3. Age, lymphvascular space invasion, and tumor volume and location were not significant parameters in surgical stage I endometrioid adenocarcinoma patients who failed. One patient had isolated pelvic failure, whereas 5 had a pure distant relapse. Three patients failed at both locoregional and distant sites. Vault recurrence coupled with distant metastasis occurred in 1 patient. Three patients (33.33%) with recurrences, all with limited relapse sites, were salvaged, with a mean survival of 71.33 months. The median survival for recurrent endometrial cancer was 5 years.Conclusions: This treatment has excellent survival rates with acceptable morbidity, and recurrence is mostly distant. ER -