PT  - JOURNAL ARTICLE
AU  - Cornelis D. de Kroon
AU  - Ellen Hiemstra
AU  - J. Baptist Trimbos
AU  - Frank Willem Jansen
TI  - Power Doppler Area in the Diagnosis of Endometrial Cancer
AID  - 10.1111/IGC.0b013e3181f0df98
DP  - 2010 Oct 01
TA  - International Journal of Gynecologic Cancer
PG  - 1160-1165--1160-1165
VI  - 20
IP  - 7
4099  - http://ijgc.bmj.com/content/20/7/1160-1165.short
4100  - http://ijgc.bmj.com/content/20/7/1160-1165.full
SO  - Int J Gynecol Cancer2010 Oct 01; 20
AB  - Objective: To evaluate the diagnostic accuracy of power Doppler area (PDA) in the detection of endometrial cancer in women with postmenopausal bleeding.Design: Prospective diagnostic study.Setting: University hospital.Population: Seventy-four consecutive women presenting with postmenopausal bleeding and a total endometrial thickness of more than 4 mm.Methods: The PDA was measured by pelvic ultrasound. Endometrial cancer and hyperplasia with complex atypia were considered abnormal.Main Outcome Measures: A receiver operating characteristic curve was constructed and area under curve (AUC) calculated as well as positive and negative likelihood ratios (LR+ and LR−).Results: Eighteen women (24%) had abnormal results of their histological specimen. The AUC of the PDA was 0.88 (95% confidence interval [CI], 0.80-0.98). The LR+ and LR− of the PDA were, respectively, 14.5 (95% CI, 4.69-44.9) and 0.23 (95% CI, 0.09-0.55). In women with total endometrial thickness of 4 to 10 mm, the AUC, LR+, and LR− were, respectively, 0.91 (95% CI, 0.78-1.00), 23.9 (95% CI, 3.29-175.0), and 0.34 (95% CI, 0.13-0.86).Conclusions: The PDA is an effective measure in the diagnosis and exclusion of endometrial cancer.