@article {de Kroon1160-1165, author = {Cornelis D. de Kroon and Ellen Hiemstra and J. Baptist Trimbos and Frank Willem Jansen}, title = {Power Doppler Area in the Diagnosis of Endometrial Cancer}, volume = {20}, number = {7}, pages = {1160-1165--1160-1165}, year = {2010}, doi = {10.1111/IGC.0b013e3181f0df98}, publisher = {BMJ Specialist Journals}, abstract = {Objective: To evaluate the diagnostic accuracy of power Doppler area (PDA) in the detection of endometrial cancer in women with postmenopausal bleeding.Design: Prospective diagnostic study.Setting: University hospital.Population: Seventy-four consecutive women presenting with postmenopausal bleeding and a total endometrial thickness of more than 4 mm.Methods: The PDA was measured by pelvic ultrasound. Endometrial cancer and hyperplasia with complex atypia were considered abnormal.Main Outcome Measures: A receiver operating characteristic curve was constructed and area under curve (AUC) calculated as well as positive and negative likelihood ratios (LR+ and LR-).Results: Eighteen women (24\%) had abnormal results of their histological specimen. The AUC of the PDA was 0.88 (95\% confidence interval [CI], 0.80-0.98). The LR+ and LR- of the PDA were, respectively, 14.5 (95\% CI, 4.69-44.9) and 0.23 (95\% CI, 0.09-0.55). In women with total endometrial thickness of 4 to 10 mm, the AUC, LR+, and LR- were, respectively, 0.91 (95\% CI, 0.78-1.00), 23.9 (95\% CI, 3.29-175.0), and 0.34 (95\% CI, 0.13-0.86).Conclusions: The PDA is an effective measure in the diagnosis and exclusion of endometrial cancer.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/20/7/1160-1165}, eprint = {https://ijgc.bmj.com/content/20/7/1160-1165.full.pdf}, journal = {International Journal of Gynecologic Cancer} }