PT - JOURNAL ARTICLE AU - Dimitrios Nasioudis AU - Spyridon A Mastroyannis AU - Emily M Ko AU - Ashley F Haggerty AU - Lori Cory AU - Robert L Giuntoli II AU - Sarah H Kim AU - Nawar A Latif TI - Safety of ovarian preservation for premenopausal patients with FIGO stage I grade 2 and 3 endometrioid endometrial adenocarcinoma AID - 10.1136/ijgc-2022-003450 DP - 2022 Nov 01 TA - International Journal of Gynecologic Cancer PG - 1355--1360 VI - 32 IP - 11 4099 - http://ijgc.bmj.com/content/32/11/1355.short 4100 - http://ijgc.bmj.com/content/32/11/1355.full SO - Int J Gynecol Cancer2022 Nov 01; 32 AB - Objective To investigate the utilization and outcomes of ovarian preservation for premenopausal patients with International Federation of Gynecology and Obstetrics (FIGO) stage I grade 2 and 3 endometrioid endometrial carcinoma undergoing hysterectomy.Methods The National Cancer Database was accessed; patients aged ≤45 years diagnosed between January 2004 and December 2015 with FIGO stage I grade 2 or 3 endometrioid endometrial carcinoma, who underwent hysterectomy with or without bilateral salpingo-oophorectomy and had at least 1 month of follow-up, were identified. Overall survival was assessed following generation of Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for a priori selected variables.Results A total of 2941 patients who met the inclusion criteria were identified; 200 (6.8%) patients did not undergo bilateral salpingo-oophorectomy. Rate of ovarian preservation was comparable between patients with grade 2 (n=163, 6.6%) and grade 3 (n=37, 7.7%) tumors (p=0.38). Patients who did not undergo bilateral salpingo-oophorectomy were younger (median 39 vs 41 years, p<0.001) and less likely to undergo surgical lymph node assessment (52% vs 76.2%, p<0.001). There was no difference in overall survival between patients who did and did not undergo bilateral salpingo-oophorectomy (p=0.94); 5 year overall survival rates were 96.6% and 97%, respectively. After controlling for confounders, including tumor grade, ovarian preservation was not associated with worse overall survival (HR 0.92, 95% CI 0.47 to 1.84).Conclusions For patients with grade 2 and 3 FIGO stage I endometrioid carcinoma undergoing hysterectomy, ovarian preservation is rarely performed while no clear detrimental effect on overall survival was found.Data may be obtained from a third party and are not publicly available. Data available following request from the American College of Surgeons.