PT  - JOURNAL ARTICLE
AU  - Pei Wang
AU  - Xiaodong Cheng
AU  - Zhiqin Fu
AU  - Caiyun Zhou
AU  - Weiguo Lu
AU  - Xing Xie
TI  - Reduced Expression of NDUFS3 and Its Clinical Significance in Serous Ovarian Cancer
AID  - 10.1097/IGC.0b013e318287a90d
DP  - 2013 May 01
TA  - International Journal of Gynecologic Cancer
PG  - 622--629
VI  - 23
IP  - 4
4099  - http://ijgc.bmj.com/content/23/4/622.short
4100  - http://ijgc.bmj.com/content/23/4/622.full
SO  - Int J Gynecol Cancer2013 May 01; 23
AB  - Objective Expression of the mitochondrial protein, nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Fe-S protein 3 (NDUFS3), down-regulates in some cancers including breast and kidney. This study evaluates NDUFS3 expression and its clinical significance in human serous ovarian adenocarcinoma.Methods 30 ovarian normal epithelium, 30 benign serous adenoma, and 100 serous carcinoma tissues were collected, and the expression of NDUFS3 protein and messenger RNA was evaluated by immunohistochemistry, Western blot, and real-time reverse transcription–polymerase chain reaction, respectively. Relationships between NDUFS3 protein expression and clinicopathologic parameters and disease-free and overall survival were also studied.Results The expression of NDUFS3 messenger RNA and protein was significantly decreased in serous ovarian adenocarcinoma compared with normal ovarian epithelium and benign serous adenoma (both P < 0.001). Reduced NDUFS3 immunostaining correlated with advanced Federation of Gynecology and Obstetrics stage (P = 0.002) and suboptimal residual disease after primary surgery (P = 0.021). Reduced NDUFS3 expression also correlated with shorter disease-free (P = 0.002) and overall survival (P = 0.004).Conclusions NDUFS3 expression is down-regulated in serous ovarian adenocarcinoma, suggesting that NDUFS3 may contribute to the development of serous ovarian cancer.