PT  - JOURNAL ARTICLE
AU  - Yih Harng Chong
AU  - Archibald John Campbell
AU  - Stephanie Farrand
AU  - Ian S. McLennan
TI  - Anti-Müllerian Hormone Level in Older Women: Detection of Granulosa Cell Tumor Recurrence
AID  - 10.1097/IGC.0b013e318270ac69
DP  - 2012 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1497--1499
VI  - 22
IP  - 9
4099  - http://ijgc.bmj.com/content/22/9/1497.short
4100  - http://ijgc.bmj.com/content/22/9/1497.full
SO  - Int J Gynecol Cancer2012 Nov 01; 22
AB  - Objective To determine whether anti-Müllerian hormone (AMH) production resumes during normal late menopausal aging. Anti-Müllerian hormone has been proposed as a specific serum marker for adult granulosa cell tumors.Materials and Methods Serum AMH from 21 elderly postmenopausal women (mean age, 77 years) and 9 young women (mean age, 22 years) were measured by ultrasensitive immunoassay.Results Both median (0 pmol/L) and mean (0.48 pmol/L) serum AMH values for the elderly women were below the level of detection for the immunoassay kit. Three of the 21 participants had minimally detectable level of AMH (1.13–2.76 pmol/L). The cohort of young women had expected normal values of AMH as measurable by the same immunoassay kit.Conclusions Serum AMH values were negligible for postmenopausal women older than 65 years. This extends the normative data for AMH to 108 years old, providing a reference range for the detection of granulosa cell tumors in postmenopausal women.