TY - JOUR T1 - Anti-Müllerian Hormone Level in Older Women: Detection of Granulosa Cell Tumor Recurrence JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1497 LP - 1499 DO - 10.1097/IGC.0b013e318270ac69 VL - 22 IS - 9 AU - Yih Harng Chong AU - Archibald John Campbell AU - Stephanie Farrand AU - Ian S. McLennan Y1 - 2012/11/01 UR - http://ijgc.bmj.com/content/22/9/1497.abstract N2 - Objective To determine whether anti-Müllerian hormone (AMH) production resumes during normal late menopausal aging. Anti-Müllerian hormone has been proposed as a specific serum marker for adult granulosa cell tumors.Materials and Methods Serum AMH from 21 elderly postmenopausal women (mean age, 77 years) and 9 young women (mean age, 22 years) were measured by ultrasensitive immunoassay.Results Both median (0 pmol/L) and mean (0.48 pmol/L) serum AMH values for the elderly women were below the level of detection for the immunoassay kit. Three of the 21 participants had minimally detectable level of AMH (1.13–2.76 pmol/L). The cohort of young women had expected normal values of AMH as measurable by the same immunoassay kit.Conclusions Serum AMH values were negligible for postmenopausal women older than 65 years. This extends the normative data for AMH to 108 years old, providing a reference range for the detection of granulosa cell tumors in postmenopausal women. ER -