RT Journal Article
SR Electronic
T1 2022-RA-1340-ESGO Effect of alpha-lipoic acid supplementation on oxidative stress markers in patients with lsil
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A54
OP A54
DO 10.1136/ijgc-2022-ESGO.118
VO 32
IS Suppl 2
A1 Divković, Anja
A1 Bilić, Paula
A1 Ivanko, Marta
A1 Zonjić, Iva
A1 Radić, Kristina
A1 Golub, Nikolina
A1 Rajković, Marija Grdić
A1 Rumora, Ivana
A1 Stojanovic, Ivana
A1 Butorac, Dražan
A1 Čepo, Dubravka Vitali
YR 2022
UL http://ijgc.bmj.com/content/32/Suppl_2/A54.2.abstract
AB Introduction/Background The goal of study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with low-grade squamous intraepithelial lesion (LSIL).Methodology One hundred (100) patients diagnosed with LSIL were randomized to receive 600 mg/day of LA (treatment group-T) or placebo (control-C) for three months. Ninety (90) patients finished the study (40 controls and 50 treated). Venous blood was collected for analysis of oxidative stress markers (plasma ferric reducing power (FRAP), superoxide dismutase (SOD) activity, reduced glutathione levels (GSH) and malondialdehyde levels (MDA)) at baseline and at 90th day of supplementation. All patients were instructed to fulfil validated food frequency questionary (FFQs) to investigate average intake of food derived antioxidants (number of fruit/vegetable portions and intake of nutrients with antioxidative potency). The normality of the distribution of obtained data was tested using the D’Agostino – Pearson test. Obtained values were presented as median ± 95% confidence range and comparison of results (before-after supplementation/control-tested) was performed using the Mann-Whitney U test for the significance level p <0.05.Results There were no significant differences between baseline FRAP, SOD, GSH and MDA levels between patients in control and treatment group. LA supplementation didn`t significantly impact SOD GSH or MDA levels but it increased TAC values, although observed changes were not statistically significant (p=0.0893). FFQ analysis revealed vegetable intake significantly affected baseline FRAP values-they were significantly lower in the group of patients with the lowest vegetable intake (4th quartile) in comparison to the group with the highest vegetable intake (1st quartile) (p=0.0116).Conclusion LA supplementation in investigated regime (300 mg/day for 3 months) was not effective in improving oxidative status parameters in patients with LSIL. Analysis of FFQs revealed that nutritional patterns, rather than supplementation with antioxidant, can have significant impact on plasma antioxidant status in LSIL patients.