PT - JOURNAL ARTICLE AU - Nicolò Bizzarri AU - Francesco Legge AU - Valerio Gallotta AU - Luigi Pedone Anchora AU - Francesco Cosentino AU - Luigi Carlo Turco AU - Camilla Certelli AU - Gabriella Macchia AU - Vincenzo Valentini AU - Giovanni Scambia AU - Gabriella Ferrandina TI - 2022-RA-201-ESGO Locally advanced cervical carcinoma patients treated with chemoradiation followed by radical surgery: clinical response and oncological outcomes according to histotype after propensity score analysis AID - 10.1136/ijgc-2022-ESGO.8 DP - 2022 Oct 01 TA - International Journal of Gynecologic Cancer PG - A3--A3 VI - 32 IP - Suppl 2 4099 - http://ijgc.bmj.com/content/32/Suppl_2/A3.2.short 4100 - http://ijgc.bmj.com/content/32/Suppl_2/A3.2.full SO - Int J Gynecol Cancer2022 Oct 01; 32 AB - Introduction/Background The aims of this study were to analyze the pathological response, and survival outcomes of adenocarcinoma/adenosquamous (AC/ASC) versus squamous cell carcinoma (SCC) in patients with locally advanced cervical cancer (LACC) managed by chemoradiotherapy followed by radical surgery.Methodology Retrospective, multicenter, observational study, including patients with SCC and AC/ACS LACC patients treated with preoperative CT/RT followed by tailored radical surgery (RS) between 06/2002 and 05/2017. Clinical-pathological characteristics were compared between patients with SCC versus AC/ASC. A 1:3 ratio propensity score (PS) matching was applied to remove the variables imbalance between the two groups.Results After PS, 320 patients were included, of which 240 (75.0%) in the SCC group, and 80 (25.0%) in the AC/ASC group. Clinico-pathological and surgical baseline characteristics were balanced between the two study groups. Percentage of pathologic complete response was 47.5% in SCC patients versus 22.4% of AC/ASC ones (p<0.001). With a median follow-up of 51 months (range:1–199), there were 54/240 (22.5%) recurrences in SCC versus 28/80 (35.0%) in AC/ASC patients (p=0.027). AC/ASC patients experienced worse disease free (DFS), and overall survival (OS) compared to SCC patients (p=0.019, and p=0.048, respectively). In multivariate analysis, AC/ACS histotype, and FIGO stage were associated with worse DFS and OS.Conclusion In LACC patients treated with CT/RT followed by RS, AC/ASC histology was associated with lower pathological complete response to CT/RT, and higher risk of recurrence and death compared with SCC patients. This highlights the need for specific therapeutic strategies based on molecular characterization to identify targets and develop novel treatments.