RT Journal Article SR Electronic T1 2022-RA-1433-ESGO Reproductive outcomes after conservative treatment in malignant ovarian germ cell tumors (MOGCTs) patients: a MITO-9 study JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP A180 OP A180 DO 10.1136/ijgc-2022-ESGO.386 VO 32 IS Suppl 2 A1 Alice Bergamini A1 Francesca Vasta A1 Luca Bocciolone A1 Giovanna Scarfone A1 Chiara Cassani A1 Gabriella Ferrandina A1 Rocco de Vivo A1 Saverio Danese A1 Marianna Di Filippo A1 Elisa Grassi A1 Gennaro Cormio A1 Sandro Pignata A1 Giorgia Mangili YR 2022 UL http://ijgc.bmj.com/content/32/Suppl_2/A180.2.abstract AB Introduction/Background Malignant ovarian germ cell tumours (MOGCTs) are rare tumours mainly affecting women in reproductive age, hence fertility preservation is of paramount importance. The mainstay of treatment is fertility sparing surgery (FSS) followed by active surveillance in selected cases or multidrug BEP (bleomycin, cisplatin, etoposide) chemotherapy. Evidence available on fertility following treatment of MOGCTs is scanty.The aim of this study is to evaluate the reproductive outcomes of patients treated with FSS for MOGCTs in MITO centres (Multicentre Italian trials in gynecologic oncology).Methodology All the included patients were treated conservatively, both in primary surgery and for relapse. The indication on adjuvant chemotherapy in stage I disease varies among centres. Patients were sent a questionnaire evaluating their desire of conception, fertility and endocrine outcomes. Data were analyzed with descriptive statistics. Univariate and multivariate analyses were used to assess correlation between fertility outcomes and clinicopathological variables.Results 164 patients were sent the questionnaire, that was completed by 114 patients (69.5%). Among all patients, 38 (33.3%) expressed a desire for pregnancy, 29 (76.3%) of which successfully conceived. 62.1% patients who conceived received adjuvant chemotherapy. 97,7% conceptions occurred spontaneously. Six patients entered menopause after treatment (5.3%), 5 of whom received chemotherapy. No statistically significant difference was detected in terms of fertility outcomes between patients receiving adjuvant chemotherapy and those addressed to surveillance. When analysing factors affecting the pregnancy rate, the desire of conception was the only statistically significant factor.Conclusion The results of the present study suggest that fertility outcomes in MOGCTs patients despite surgery and chemotherapy are very promising. The only factor significantly affecting the pregnancy rate after a MOGCTs diagnosis is the desire of conception.