RT Journal Article
SR Electronic
T1 2022-RA-685-ESGO What is beyond brca mutational status in high grade serous ovarian cancer? The role of hormone receptors expression
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A254
OP A254
DO 10.1136/ijgc-2022-ESGO.544
VO 32
IS Suppl 2
A1 Emanuele Perrone
A1 Riccardo Tudisco
A1 Pia Clara Pafundi
A1 Davide Guido
A1 Alessandra Ciucci
A1 Enrica Martinelli
A1 Gian Franco Zannoni
A1 Alessia Piermattei
A1 Claudia Marchetti
A1 Camilla Nero
A1 Daniela Gallo
A1 Giovanni Scambia
A1 Anna Fagotti
YR 2022
UL http://ijgc.bmj.com/content/32/Suppl_2/A254.1.abstract
AB Introduction/Background Several studies have explored the prognostic role of hormone receptor status in high grade serous ovarian cancer (HGSOC). However, few reports have investigated their expression according to BRCA mutational status. Notably, there is evidences of a strong interaction between BRCA1/2 proteins and steroid hormones system, including higher titres of estradiol and progesterone in BRCA1/BRCA2 mutation carriers. Thus, we sought to explore the hormone receptor pattern and its potential prognostic impact in a well-characterized cohort of HGSOC patients stratified for BRCA status.Methodology We assessed ERα, ERβ1, ERβ2, ERβ5, PR (progesterone receptor) and AR (androgen receptor) expression by immunohistochemistry in a single-centre observational retrospective cohort study of 207 HGSOC women, profiled for BRCA-1/2 mutation status with available clinical and molecular features.Results 135 BRCA-wild type (BRCA-wt) and 72 BRCA1/2 mutation carriers (BRCA-mut) were observed. No significant differences were detected in hormone receptor expression between the two populations. However, in the subgroup analysis according to menopausal status, a significantly lower ERα expression was found in pre-menopausal BRCA-mut compared to BRCA-wt patients (p=0.02) (figure 1). Regarding survival analysis, none of the examined hormone receptors had a significant prognostic role. However, a higher ERα/ERβ5nuclear ratio differently affected outcome according to BRCA status: positively in BRCA-wt cohort (HR 0.77; CI 0.61–0.96; p=0.019) and negatively in BRCA-mut cohort (HR 1.41; CI 1.06–1.87; p=0.020) (table 1). Finally, higher PR levels were associated with platinum sensitivity in the whole population (p=0.019).Abstract 2022-RA-685-ESGO Figure 1 View this table:Abstract 2022-RA-685-ESGO Table 1 Survival analysis on BRCA-wt vs. BRCA mutated (n=207)Conclusion This study suggests a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential of targeting this interaction.