RT Journal Article
SR Electronic
T1 Nomogram Predicting Overall Survival in Operable Cervical Cancer Patients
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 987
OP 993
DO 10.1097/IGC.0000000000000987
VO 27
IS 5
A1 Zheng, Ru-ru
A1 Huang, Xiao-wan
A1 Liu, Wen-Yue
A1 Lin, Rong-rong
A1 Zheng, Fei-yun
A1 Lin, Feng
YR 2017
UL http://ijgc.bmj.com/content/27/5/987.abstract
AB Objective Nomograms are widely used as predictive tools to predict oncological outcomes intuitively and precisely. The aim of our study was to develop a nomogram for predicting overall survival (OS) of patients with early stage cervical cancer.Methods In this retrospective study, the clinical, pathological, and hematological data and prognosis of 795 cervical cancer patients were investigated. We identified and incorporated independent significant prognostic factors for OS to develop a nomogram. The predictive accuracy and discriminative ability were measured by concordance index.Results By univariable analysis and subsequent multivariable analysis, we identified body mass index, albumin, platelet, leukocyte, tumor differentiation, and the status of the pelvic lymph node (PLN) (all P < 0.05) as independent prognostic factors. The concordance index of the nomogram integrating these 6 variables was 0.74. The calibration curves for probability of 3- and 5-year OS also demonstrated ideal agreement between nomogram prediction and actual observation.Conclusions We developed a novel nomogram that can provide prediction of OS for patients with early stage cervical cancer individually. Furthermore, studies are required to validate whether it can be applied to other cohorts.