RT Journal Article SR Electronic T1 Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome: A French Multicenter Study JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 953 OP 960 DO 10.1097/IGC.0000000000000985 VO 27 IS 5 A1 Léa Rossi A1 Marie-Aude Le Frere-Belda A1 Pierre Laurent-Puig A1 Bruno Buecher A1 Antoine De Pauw A1 Dominique Stoppa-Lyonnet A1 Geoffroy Canlorbe A1 Olivier Caron A1 Bruno Borghese A1 Chrystelle Colas A1 Hélène Delhomelle A1 Nathalie Chabbert-Buffet A1 Sophie Grandjouan A1 Fabrice Lecuru A1 Anne-Sophie Bats YR 2017 UL http://ijgc.bmj.com/content/27/5/953.abstract AB Background Limited data exist on Lynch syndrome (LS)–related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed.Aim The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients.Methods We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation. We analyzed the clinical data and the pathology of the tumors. The patient management and the survival data were also collected.Results Forty-nine patients (15 MLH1, 20 MSH2, 13 MSH6, 1 PMS2) were included. The mean age at diagnosis was 49.7 (SD, 10.5) years. The median body mass index was 22.6 kg/m2. In 81.4% of cases, EC was the first cancer of the LS spectrum to occur. Endometrioid adenocarcinoma accounted for 89.2% of the EC, the lower uterine segment was involved in 25% of cases, and a synchronous ovarian cancer was present in 21.6% of patients. The tumors were grade 3 in 19.3% of cases and FIGO (International Federation of Gynecology and Obstetrics) stage I in 66.6% of cases. With a median follow-up of 58 months, 3 patients with conservative management developed a recurrence, and no patient died of EC.Conclusions The LS-associated EC is characterized by a young age at onset, a high prevalence of lower uterine segment involvement, and synchronous ovarian cancers. The prognosis of these cancers does not appear different from sporadic tumors.